Breeding pinto bean for resistance to diseases has been carried out for more than 50 years in the U.S. The objective of this research was to determine the reaction of landraces, cultivars, and breeding lines developed by private and public institutions since 1940’s. Fifty-nine genotypes were evaluated for anthracnose, Bean common mosaic virus (BCMV), common and halo bacterial blights, rust, and white mold in separate trials in the greenhouse in Idaho from 2004 to 2006. Six (10%) genotypes were resistant or intermediate to anthracnose, 21 (35%) to BCMV, 17 (29%) to rust, 2 (3%) to halo blight, and none to common bacterial blight and white mold. Only nine (15%) genotypes carried similar reaction to two, only USPT-ANT-1 for three, and none for four or more diseases. Strategies for expediting breeding for resistance to multiple-diseases will be discussed.