Changes in volume and pore space induced by the shrink-swell behavior of clay minerals present a challenge to predictive modeling of hydraulic and swelling properties of clayey porous materials. A pore-scale framework that combines physico-chemical processes with pore-geometrical, hydrostatic, and hydrodynamic considerations toward prediction of constitutive hydraulic relationships for swelling porous media will be presented. Measurements of shrink-swell and hydraulic properties of clayey soils are used to evaluate model predictions. The roles of solution chemistry and confining conditions will be discussed.