Conservation tillage in wheat (Triticum aestivum L.) monoculture has been tempered by concerns about tan spot (Pyrenophora tririci-repentis) on the surface residue. Tan spot over winters on the previous wheat residue and infects the new wheat when rainstorms move inoculum from the residue to the growing wheat. The objective of this study was to evaluate two wheat varieties: 2145 (susceptible to tan spot) and Overley (moderately resistant), with three residues management treatments: no-till, burned, and disked in a continuous wheat rotation. Presence and absence of Tan Spot was controlled by the use of fungicide. Within each fungicide (F) or non fungicide (NF) plot three rate of fertilizer (70, 100, and 130 kg/ha) were applied to evaluate the effect of surface applied fertilizer. The experiment was replicated at two locations in Kansas (Marysville and Salina). Residues management and nitrogen did not affect grain yield at any of the two locations. However, differences between varieties and fungicide treatments were observed. At both locations, grain yield of 2145 with fungicide was higher than without fungicide. Overley presented similar yields when fungicide was or was not applied at Marysville, but grain production increased with fungicide at Salina due a higher percentage of the flag leaves that were affected by stripe rust (Puccinia striformis) and powdery mildew (Blumeria graminis f. sp. tritici). Overley with NF produced more than 2145 NF at Marysville due the moderated resistance to tan spot, but this difference was not observed at Salina because of the severity of stripe rust and powdery mildew on the Overley.