Considerable attention has been given to deployment of the low phytic acid (lpa) trait in maize and barley. The lpa trait can improve the bioavailability of phosphorus in livestock P, thus reducing P in the waste stream. Since our laboratory identified a low phytic acid wheat (lpa) genotype, Js-12-LPA, we have been working to incorporate the lpa phenotype into commercial wheat cultivars. Segregation in an F6-derived mapping population, as well as our experience with backcrossing the phenotype, is consistent with multigenic inheritance of the full lpa phenotype from the initial Js-12-LPA genotype. Field trials with backcross sib families have indicated that some yield drag is associated with the lpa phenotype. However, we believe that effective breeding can result in lpa cultivars with commercially competitive yields. The end-use quality effects of the lpa phenotype are limited to an increase in flour ash concentration, associated with higher mineral concentration in the central endosperm. The lpa phenotype derived from Js-12-LPA is not associated with an increase in phytase activity. Therefore, the lpa trait may be coupled to elevated endogenous phytase to further improve the nutritional profile of whole grain wheat products and the animal feed value of wheat bran.