Irrigation with coalbed natural gas (CBNG) produced water is a popular management option used by many gas companies operating in northwestern Powder River Basin (PRB). The cumulative CBNG-water production during the period 2002-2017 is estimated to be 366,000 ha-m. The quality of CBNG water [high sodium (Na) content] is variable within the region and is often not suitable for direct irrigation. A laboratory study was conducted to examine changes in soil chemical properties from leaching CBNG water, both with and without chemical amendments, through representative surface soils. Surface soil samples (0-15 cm) that had not received CBNG water irrigation were collected from the northwestern PRB, processed, and uniformly packed in columns to simulate the bulk densities recorded in the field. Representative CBNG water samples were collected and analyzed for chemical properties. Based on the Na and HCO3- contents of the CBNG water, required quantities of gypsum and reduced sulfur (S) were applied to soil columns. A mechanical vacuum extractor was used to leach soil columns with CBNG water and the three replications of each treatment (gypsum, S, gypsum + S and control) were included. The amount of CBNG water applied to each column simulated amounts of CBNG water being added to fields by various gas companies. As expected, significant (P<0.05) differences in chemical properties were observed between amended and control soils. Gypsum + S treatments were most efficient in replacing Na on soil exchange sites followed by Gypsum alone treatments. Exchangeable sodium percent (ESP) and SAR of S-amended and control soils did not differ significantly. Results of this column experiment will be complementary to the field experiment being carried out to evaluate the changes in soil properties due to irrigation with saline-sodic CBNG water in the PRB region.