Rhizoma perennial peanut (Arachis glabrata Benth.) is a vegetatively propagated forage legume that has potential wildlife value. It has similar nutritive value to alfalfa (Medicago sativa), which could provide high level of nutrition in late summer when forage is limited. Due to the rhizomatous growth habit, it has persisted in fields with cotton root rot (Phymatotrichum omnivorum), which is prevalent in the North Texas. Previous research in Texas identified two lines (PI 262819 and PI 262821 both from Paraguay), that were superior to 'Arbrook' and 'Florigraze' for establishment, rate of spread, and persistence. The objective is this study was to evaluate herbicides labeled for alfalfa during the establishment of perennial peanut. PI 262819 was planted 5 to 7 cm deep in plots by hand on 16 March 2004. Plot size consisted of two rows, 0.9 m apart or 1.8 x 7.6 m. Nine herbicide treatments were applied after sprigging perennial peanut, which was compared to a traditional post-emergent treatment used in alfalfa [Butyrac (2,4-DB) plus Select (clethodim)]. Percent Texas panicum (Panicum texanum) control, percent visual injury, percent ground cover, and dry matter (DM) yield of perennial peanut was estimated. Diuron, imazapic, and metribuzin injured perennial peanut 80, 60, and 80% respectively, and resulted in 10, 25, and 10% ground cover, respectively, 120 days after planting (DAP). Benefin, trifluralin, pronamide, and 2,4-DB plus clethodim provided adequate control of Texas panicum without visual injury to the perennial peanut, which resulted in 50-60% ground cover 120 DAP and 70-85% groundcover 240 DAP. These data illustrate the importance of controlling weeds without injury to perennial peanut during establishment.