Vegetative growth in cotton (Gossypium hirsutum) has been controlled in recent years with a variety of plant growth regulators (PGRs), particularly mepiquat chloride. However, a new product shows potential as a new PGR. This product is composed of mepiquat chloride, which is used in most cotton PGRs, and a new chemical, cyclanilide, a presumed auxin transport inhibitor. A combination of mepiquat chloride and cyclanilide shows potential as a new PGR. This combination was compared with the traditional mepiquat chloride regime for application rate, effects on plant height, and effects on fruiting under irrigated and dryland conditions. A combination of mepiquat chloride and cyclanilide can produce similar growth effects on cotton with less chemical than a mepiquat chloride regime alone. It is also suggested that the combination of these two chemicals may offer a quicker response that just mepiquat chloride alone. Other physiological affects on cotton that might influence production and harvest methods, quality, and yield are also being determined