Blue grama [Bouteloua gracilis (H.B.K.) Lag. ex Steud.] is a warm-season grass species that has shown potential as a reduced-input turfgrass. Weed competition can delay establishment of newly seeded blue grama and reduce quality of blue grama turf. Research was conducted in 2006 and 2007 to evaluate the safety of preemergence herbicides applied directly after seeding blue grama. Preemergence control of large crabgrass [Digitaria sanguinalis ( L.) Scop.] and common purslane (Portulaca oleracea L.) was also evaluated. Seeded blue grama exhibited acceptable tolerance to imazapic and metsulfuron-methyl, while moderate susceptibility was observed with both siduron and quinclorac. Mesotrione, pendimethalin, isoxaflutole, dithiopyr, and simazine all severely injured blue grama when applied at seeding time.